Status:
RECRUITING
A Study on Using SFRT With Standard Treatment for Oligoprogressive NSCLC
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions:
Non Small Cell Lung Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to learn if spatially fractionated radiotherapy (SFRT) combined with standard systemic therapy can treat oligoprogressive non-small cell lung cancer (NSCLC) in patie...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age 18 years or older, regardless of sex.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 2 or less, with an expected survival of more than 3 months.
- Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) with oligometastatic disease (up to 5 separate progressive lesions), having received and progressed after at least one line of systemic therapy (chemotherapy, targeted therapy, or immunotherapy).
- The target lesion for radiotherapy has not been previously irradiated, or it has been more than 6 months since the last radiotherapy.
- The diameter of the target lesion is at least 4.5 cm, suitable for lattice radiotherapy planning.
- No new or enlarged brain metastases; if brain metastases were previously treated with standard radiotherapy, they must be stable.
- Adequate hematologic and biochemical profiles, including hemoglobin ≥9.0 g/dL, absolute neutrophil count (ANC) ≥1500/mm³, platelet count ≥100,000/mm³, total bilirubin ≤1.5 times the upper limit of normal (ULN) (or direct bilirubin ≤ULN if total bilirubin \>1.5 times ULN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 times ULN (or ≤5 times ULN if liver involvement is present), and creatinine ≤1.5 times ULN (or glomerular filtration rate \[GFR\] \>60 mL/min if creatinine \>1.5 times ULN).
- For women of childbearing potential, a negative pregnancy test within 7 days prior to registration.
- Exclusion Criteria
- Presence of other systemic diseases or severe comorbidities that the investigator believes would make the patient unsuitable for the study or significantly interfere with the assessment of the safety and toxicity of the study regimen.
- Active autoimmune diseases requiring systemic treatment, or a history of severe autoimmune diseases, such as interstitial lung disease.
- Uncontrolled concurrent diseases, including but not limited to: infections requiring systemic treatment, active tuberculosis (TB), severe or chronic gastrointestinal diseases associated with diarrhea (e.g., Crohn's disease), active hepatitis B (defined by positive hepatitis B surface antigen \[HBsAg\]), active hepatitis C (defined by positive hepatitis C virus \[HCV\] RNA), symptomatic congestive heart failure, unstable angina, unstable cardiac arrhythmias, myocardial infarction within the past 6 months, or congestive heart failure requiring continuous maintenance therapy for life-threatening ventricular arrhythmias.
- Mental illness or social situations that might limit the patient's ability to comply with study requirements (e.g., drug abuse).
- Participation in other interventional clinical trials with experimental drugs that could be considered treatment for the primary tumor.
- Allergy to immunotherapy drugs, or discontinuation of immunotherapy drugs due to adverse events in the past, or grade 3 or higher immune-related adverse events during previous immunotherapy, or any grade of immune-related neurological or ocular adverse events.
- History of other active malignancies within the past 6 months, except for non-melanoma skin cancer, papillary thyroid cancer, prostate cancer, or cervical carcinoma in situ that have been treated with curative intent and are currently considered to have a recurrence risk of less than 30%.
- History of allogeneic organ transplantation or active primary immunodeficiency.
- Any other condition that the investigator deems a valid reason for exclusion, such as potential situations inconsistent with the clinical protocol.
Exclusion
Key Trial Info
Start Date :
June 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 15 2028
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT07193641
Start Date
June 15 2025
End Date
June 15 2028
Last Update
September 26 2025
Active Locations (1)
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1
2nd Affiliated Hospital, School of Medicine
Hangzhou, Zhejiang, China, 310000