Status:
ENROLLING_BY_INVITATION
Synergistic Effect of Intravenous Lidocaine on Anesthetic Induction and Emergence in Patients Undergoing Laparoscopic Cholecystectomy or Gynecological Surgery
Lead Sponsor:
General Hospital of Ningxia Medical University
Conditions:
Cholecystectomy, Laparoscopic
Gynecologic Surgical Procedures
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This study aims to evaluate the effect of intravenous lidocaine on consciousness changes during anesthesia in patients undergoing laparoscopic cholecystectomy or gynecologic surgery. A total of 150 pa...
Eligibility Criteria
Inclusion
- Adults aged 18 to 75 years.
- ASA physical status I-III.
- Scheduled for elective laparoscopic cholecystectomy, laparoscopic
- hysterectomy, or laparoscopic ovarian cystectomy.
- Expected surgical duration \< 120 minutes.
- Preoperative normal cognitive function (MoCA \> 26).
- Able and willing to provide written informed consent.
Exclusion
- Known allergy to lidocaine or other amide-type local anesthetics.
- History of severe arrhythmias, heart failure (NYHA class III or higher), or epilepsy.
- Central nervous system disorders (e.g., stroke, brain trauma, seizure disorders) or psychiatric illness.
- Severe hepatic or renal dysfunction (ALT/AST \> 2× ULN, or eGFR \< 60 ml/min/1.73 m²).
- Currently taking medications that affect CNS function (e.g., benzodiazepines, antidepressants, antiepileptics).
- Pregnant or breastfeeding women.
- History of drug or alcohol dependence.
- BMI \> 30 kg/m² or \< 18 kg/m².
- Inability to understand study procedures or refusal to sign informed consent.
Key Trial Info
Start Date :
September 25 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
195 Patients enrolled
Trial Details
Trial ID
NCT07193836
Start Date
September 25 2025
End Date
December 31 2025
Last Update
September 26 2025
Active Locations (1)
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1
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China, 750004