Status:
COMPLETED
Dietary Fiber and Probiotics in Advanced Colorectal Cancer
Lead Sponsor:
The First Hospital of Hebei Medical University
Conditions:
Colorectal Cancer (MSI-H)
Malnutrition (Calorie)
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This single-center, prospective, randomized controlled trial was conducted to evaluate the efficacy of a 12-week combined dietary fiber and probiotic supplementation on gut microbiota, immune function...
Detailed Description
Patients with advanced colorectal cancer often suffer from malnutrition and immune suppression, which can negatively impact treatment outcomes. This study investigated whether modulating the gut micro...
Eligibility Criteria
Inclusion
- Pathologically confirmed diagnosis of stage II-IV colorectal cancer post-resection.
- Receiving active adjuvant chemotherapy.
- Documented moderate-to-severe malnutrition (PG-SGA score ≥ 4).
- Ability to tolerate oral intake.
- Voluntarily signed the informed consent form.
Exclusion
- Presence of complete bowel obstruction.
- Severe, uncontrolled organ dysfunction (cardiac, hepatic, renal).
- Known allergy to any component of the nutritional supplements.
- Concurrent participation in another interventional trial.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2024
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07194954
Start Date
May 1 2022
End Date
June 1 2024
Last Update
October 1 2025
Active Locations (1)
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1
First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050000