Status:
NOT_YET_RECRUITING
Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer Using Durvalumab-680LT and Nivolumab-800CW
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
Martini Hospital Groningen
Conditions:
Esophageal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Radiation and chemotherapy can shrink the tumor. For certain types of cancer, immunotherapy is added to further reduce the tumor size. Immunotherapy works for some patients and can sometimes keep the ...
Eligibility Criteria
Inclusion
- Lesion suspected for locally advanced EC (cT1b-4a N0-3 M0);
- Indication for neoadjuvant therapy or definitive chemo-radiation therapy;
- Age ≥ 18 years;
- Written informed consent.
Exclusion
- Medical or psychiatric conditions that compromise the patient's ability to give informed consent according to treating medical physician;
- Concurrent uncontrolled medical conditions according to treating medical physician;
- Medical history of auto-immune disease and on active treatment;
- Pregnancy or breast feeding. A negative pregnancy test must be available for women of childbearing potential (i.e. premenopausal women with intact reproductive organs and women less than two years after menopause);
- Irradical endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) of the primary tumor prior to start of neoadjuvant therapy according to the patient's medical history;
- Received an investigational drug within 30 days prior to the tracer administration according to the patient's medical history;
- History of infusion reactions to durvalumab or nivolumab or other monoclonal antibodies according to the patient's medical history;
Key Trial Info
Start Date :
December 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT07196384
Start Date
December 15 2025
End Date
December 30 2026
Last Update
November 21 2025
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