Status:
RECRUITING
Transcriptomic Profiling of Cumulus Cells From CAPA-IVM
Lead Sponsor:
Mỹ Đức Hospital
Collaborating Sponsors:
Vrije Universiteit Brussel
Conditions:
PCOS (Polycystic Ovary Syndrome)
Cumulus Cell
Eligibility:
FEMALE
18-38 years
Brief Summary
Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic pr...
Detailed Description
In vitro maturation (IVM) is an alternative to conventional ovarian stimulation, particularly for women with polycystic ovary syndrome (PCOS) or at risk of ovarian hyperstimulation syndrome (OHSS). A ...
Eligibility Criteria
Inclusion
- Women 18-38 years
- BMI =\< 32kg/m2
- Diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam 2003 criteria, meet at least 2 of the following 3 features: (1) Oligo-ovulation or anovulation. (2) Clinical and/or biochemical signs of hyperandrogenism (3) Polycystic ovarian morphology on ultrasound.
- Indicated for CAPA-IVM treatment.
- Serum AMH ≥ 4 ng/mL (28.57 pmol/L).
- Antral follicle count (AFC) ≥ 24 follicles in both ovaries at the time of CAPA-IVM indication.
- Signed informed consent to participate in the study.
Exclusion
- Retrieved sperm from surgical procedures
- Previous IVF cycle with total immature oocytes
Key Trial Info
Start Date :
October 16 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 30 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT07197255
Start Date
October 16 2025
End Date
March 30 2026
Last Update
November 21 2025
Active Locations (1)
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1
My Duc Hospital
Ho Chi Minh City, Vietnam