Status:

RECRUITING

Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation

Lead Sponsor:

Capital Medical University

Collaborating Sponsors:

Beijing Rehabilitation Hospital

Conditions:

Mechanical Ventilation

Eligibility:

All Genders

18+ years

Phase:

NA

Brief Summary

This trial evaluates whether transcutaneous diaphragmatic/phrenic nerve stimulation (TEDS), abdominal functional electrical stimulation (abFES), or their combination, accelerates and improves the qual...

Eligibility Criteria

Inclusion

  • Invasive mechanical ventilation ≥21 days for PMV; expected ≥48 h ICU stay. Eligible for standardized weaning protocol and SBT assessment. Informed consent by participant or legally authorized representative.

Exclusion

  • Non-screenable/unstable arrhythmia or hemodynamics; refractory hypoxemia/hypercapnia.
  • Pacemaker/ICD not shieldable; seizure disorder uncontrolled. Recent abdominal surgery or skin breakdown at electrode sites; BMI\>35; pregnancy.
  • Prone positioning; continuous deep neuromuscular blockade; investigator deems unsuitable.

Key Trial Info

Start Date :

September 29 2025

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

July 30 2026

Estimated Enrollment :

300 Patients enrolled

Trial Details

Trial ID

NCT07199036

Start Date

September 29 2025

End Date

July 30 2026

Last Update

January 2 2026

Active Locations (1)

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Beijing Rehabilitation Hospital, Capital Medical University

Beijing, Shijingshan District, China, 100144