Status:
NOT_YET_RECRUITING
Hyperuricemia as Early Indication of CKD Progressing in Prediabetic
Lead Sponsor:
Assiut University
Conditions:
CKD Progression
Eligibility:
All Genders
18+ years
Brief Summary
Chronic kidney disease (CKD) is a major global health problem, and hyperuricemia has emerged as both a consequence and a potential driver of its progression. Elevated uric acid contributes to renal im...
Detailed Description
Chronic kidney disease (CKD) is a global health concern, characterized by a gradual loss of kidney function, and is associated with increased morbidity and mortality. Hyperuricemia, defined as elevate...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Adults aged 18 years and older.
- Diagnosed with prediabetes, defined according to the American Diabetes - - - - Association (ADA) criteria (fasting plasma glucose 100-125 mg/dL, HbA1c 5.7-6.4%, or 2-hour plasma glucose 140-199 mg/dL after oral glucose tolerance test).
- Baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m² (CKD stages 1-2).
- Willingness to provide informed consent and comply with study procedures.
- Exclusion criteria:
- Diagnosis of diabetes mellitus (fasting plasma glucose ≥126 mg/dL, HbA1c ≥6.5%).
- Established CKD stage 3 or higher (eGFR \<60 mL/min/1.73 m²).
- History of gout or current use of uric acid-lowering therapy (e.g., allopurinol, febuxostat) or acute gout.
- Use of medications known to significantly affect uric acid levels (e.g., thiazide diuretics, high-dose aspirin).
- Pregnancy or lactation.
- Presence of severe comorbid conditions (e.g., malignancy, active infection, advanced liver disease).
Exclusion
Key Trial Info
Start Date :
October 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT07199205
Start Date
October 1 2025
End Date
January 1 2027
Last Update
September 30 2025
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