Status:
RECRUITING
Hippocampal and Frontoparietal Development and Inference
Lead Sponsor:
University of Texas at Austin
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Nicole Varga
Conditions:
Healthy
Eligibility:
All Genders
13-25 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to test if an intervention used to manipulate memory and inference can improve our understanding of how brain development supports these abilities in healthy adolesc...
Detailed Description
Hippocampus (HPC) structure and its connectivity with frontoparietal regions continue to develop through adolescence, a developmental period associated with substantial gains in memory and reasoning. ...
Eligibility Criteria
Inclusion
- Right-handed
- Have normal or corrected to normal vision
- Have normal hearing
- Do not have contraindications for MRI
- Have no history of neurological or psychiatric disorders at initial intake
- Are of normal intelligence
- Native or fluent English speaker
Exclusion
- A major medical illness or a neurological disorder, or neurological abnormality including significant head trauma (loss of consciousness \> 5 min).
- Meeting criteria for any psychiatric disorder or any prior psychiatric hospitalizations
- Intelligence scores more than 1 standard deviation below the mean on the WASI-II
- History of special education placement
- Non-native English speaker
- Prior use of psychotropic medication, except antidepressants, for longer than 1 month
- History of moderate to severe cannabis use disorder, via self-report
- MRI exclusions: Claustrophobia; tattoos above the shoulders; permanent eyeliner; permanent retainer or spacer; artificial eyebrows; cardiac pacemaker; metal fragments in eye, skin, or body, including shrapnel; heart valve replacement; brain clips; venous umbrella; being a sheet-metal worker or welder; lifetime history of aneurysm surgery; intracranial bypass, renal, or aortic clips; prosthetic devices such as middle ear, eye, joint, or penile implants; joint replacements; non-removable hearing aid, neurostimulator, or insulin pump; shunts/stents; metal mesh/coil implants; metal plate/pin/screws/wires; or any other metal implants; or suspected pregnancy.
Key Trial Info
Start Date :
February 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2029
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT07199907
Start Date
February 20 2025
End Date
August 1 2029
Last Update
September 30 2025
Active Locations (1)
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1
The University of Texas at Austin
Austin, Texas, United States, 78712