Status:
NOT_YET_RECRUITING
Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine
Lead Sponsor:
Prisma Health-Upstate
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Tobacco-flavored EC
Sweet-Cooling EC
Eligibility:
All Genders
21+ years
Phase:
NA
Brief Summary
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking bu...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Age ≥21 years
- Smoke ≥5 CPD for ≥1 year
- Daily CC smoker
- Willing to switch to EC
- Exhaled CO ≥6 ppm
- Diagnosed with OUD
- Stable on bupropion treatment
- In good physical and mental health
- Able to use a smartphone
- Willing to participate in all study components
- Able to provide informed consent Exclusion Criteria
- Interested in quitting CC (contemplation stage of change)
- Use of EC on ≥4 of the past 30 days
- Use of other tobacco products (e.g., cigars, smokeless tobacco) on ≥9 days of the past 30 days
- Use of nicotine replacement therapy, smoking cessation medication, or a cessation attempt in the past 30 days
- Hypertension
- Medical condition that would contraindicate participation
- Meet DSM-V criteria for major depressive episode, psychotic episode, or manic episode
- Current suicidal ideation or suicide attempt in the past year
- Psychiatric hospitalization in the past year
- Contemplating pregnancy, currently pregnant, or breastfeeding
- Unable to speak and/or read English
Exclusion
Key Trial Info
Start Date :
January 5 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 4 2030
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT07202039
Start Date
January 5 2026
End Date
February 4 2030
Last Update
October 1 2025
Active Locations (1)
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1
Addiction Medicine Center
Greenville, South Carolina, United States, 29605