Status:
RECRUITING
Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness
Lead Sponsor:
Hospital Nord
Conditions:
Fluid Resuscitation
Fluid Responsiveness Predictability
Eligibility:
All Genders
18+ years
Brief Summary
Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of th...
Eligibility Criteria
Inclusion
- Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.
- Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.
- Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.
Exclusion
- Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) \< 30%.
- Severe right ventricular dysfunction defined by TAPSE \< 12 mm.
- Cardiac arrhythmia or atrial fibrillation.
- Abdominal compartment syndrome.
- Amputation of one or both lower limbs.
- Intracranial hypertension.
- Pregnant women (ruled out by systematic pregnancy test at ICU admission).
- Minors.
Key Trial Info
Start Date :
November 7 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
205 Patients enrolled
Trial Details
Trial ID
NCT07202637
Start Date
November 7 2024
End Date
May 1 2027
Last Update
October 2 2025
Active Locations (2)
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1
Service de réanimation polyvalente - Hopital Nord
Marseille 15, France, 13015
2
Hopital Caremeau Nimes
Nîmes, France, 30029