Status:
RECRUITING
Cervical Pre-cancer Treatment Failure Among Women Living With HIV in Zimbabwe
Lead Sponsor:
University of Bern
Collaborating Sponsors:
Krebsforschung Schweiz, Bern, Switzerland
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Uterine Cervical Neoplasms
HIV I Infection
Eligibility:
FEMALE
18-65 years
Brief Summary
The goal of this observational study is to improve cervical pre-cancer treatment outcomes among women living with HIV (WLWH), particularly in low and middle income countries (LMICs), by generating the...
Detailed Description
Background and Rationale: Cervical cancer mortality rates in Zimbabwe are among the highest in the world. Cervical cancer disproportionally affects women living with HIV (WLWH). In 2020, the World He...
Eligibility Criteria
Inclusion
- Women aged 18-65 years
- Positive HIV status confirmed through medical records
- Positive test result for any high-risk HPV genotype at preceding cervical cancer screening visit
- Cervical pre-cancer treatment required according to Newlands Clinic guidelines
- Signed informed consent
Exclusion
- Women with a history or suspicion of cervical cancer
- Women with a history of total hysterectomy (no cervix)
- Women treated for cervical pre-cancer in the past 12 months
- Pregnant women
Key Trial Info
Start Date :
May 3 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT07202936
Start Date
May 3 2024
End Date
April 1 2027
Last Update
October 2 2025
Active Locations (1)
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1
Women's Health Centre at Newlands Clinic
Harare, Zimbabwe