Status:
RECRUITING
A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes
Lead Sponsor:
FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Conditions:
Polycythemia Vera
Thrombocythemia
Eligibility:
All Genders
18-100 years
Brief Summary
International multicenter retrospective observational study consisting of two parts: a nested case-control study (part A) and a comparative retrospective cohort study (part B).
Detailed Description
The study will include ET patients (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) who are JAK2V617F positive and have progre...
Eligibility Criteria
Inclusion
- \- ET patients (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) who are JAK2V617F positive and have progressed to PV (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) by 31/12/2020. The date of PV diagnosis will be defined as the index date and this group of patients will be defined as ET-to-PV cases.
Exclusion
- None.
Key Trial Info
Start Date :
December 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2026
Estimated Enrollment :
678 Patients enrolled
Trial Details
Trial ID
NCT07203768
Start Date
December 1 2025
End Date
July 31 2026
Last Update
December 26 2025
Active Locations (25)
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1
Mayo Clinic
Rochester, Minnesota, United States, 55905-0001
2
University Hospital Halle
Halle, Germany
3
Hannover Medical School
Hanover, Germany
4
University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center
Minden, Germany