Status:
RECRUITING
PEEP-induced Effects on Respiratory dRivE and EFfort
Lead Sponsor:
Radboud University Medical Center
Collaborating Sponsors:
Università Cattolica del Sacro Cuore, Rome, Italy
Conditions:
ARDS (Moderate or Severe)
Acute Hypoxemic Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Rationale: In patients with acute hypoxemic respiratory failure (AHRF), preserving spontaneous breathing during mechanical ventilation offers physiological benefits, but also carries risks. While spo...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Acute hypoxemic respiratory failure (AHRF) with a PaO2/FiO2-ratio ≤ 200
- Patient on invasive assisted mechanical ventilation in pressure support mode exhibiting valid inspiratory efforts (occlusion pressure \> 5 cmH2O).
Exclusion
- Pre-existent neuromuscular disease
- History of chronic respiratory failure requiring long-term oxygen therapy
- Muscle paralysis
- Pneumothorax
- Contra-indication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode placement)
- Contra-indications for EAdi or oesophageal balloon catheter placement (e.g. history of gastric bypass surgery, gastro-oesophageal junction surgery, oesophageal stricture, recent upper gastrointestinal hemorrhage or known/suspected varices).
Key Trial Info
Start Date :
September 2 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07203781
Start Date
September 2 2025
End Date
September 1 2026
Last Update
November 17 2025
Active Locations (1)
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1
Radboudumc
Nijmegen, Gelderland, Netherlands, 6525 GA