Status:
NOT_YET_RECRUITING
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Collaborating Sponsors:
King's College London
Conditions:
Periodontal Diseases
Periodontitis
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving adva...
Detailed Description
This is a pilot randomised controlled trial comparing patients being treated with MINST non-surgical therapy with an adjunctive test or placebo mouthwash. This will be a single centre trial in the Dep...
Eligibility Criteria
Inclusion
- Age 18 to 70
- Diagnosis of periodontitis stage III-IV
- Presence of at least 1 deep intrabony defect (both PPD and radiographic defects \>6mm)
- Full-mouth dichotomous plaque score\>30%
- Willing to voluntarily sign the informed consent.
Exclusion
- Previous periodontal treatment to the study site within 6 months
- Use of systemic antibiotics within 3 months
- Weekly regular use of non-steroidal anti-inflammatory drugs
- Contributing medical history according to the examining clinician (e.g. diabetes mellitus)
- Smoking history (current or within 5 years)
- Allergic to any ingredient present in the products used in study.
- Presence of systemic diseases, which affects bone and/or connective tissue metabolism
- Concurrent participation in other clinical studies.
- Pregnant or breastfeeding.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07203872
Start Date
November 1 2025
End Date
May 1 2027
Last Update
October 2 2025
Active Locations (1)
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1
Oral Clinical Research Unit (OCRU) at King's College London (KCL)
London, United Kingdom, SE1 9RT