Status:
NOT_YET_RECRUITING
Semitendinosus Autograft vs Meniscal Allograft in Post-Meniscectomy Syndrome
Lead Sponsor:
Chang Gung Memorial Hospital
Collaborating Sponsors:
Karolinska University Hospital
Conditions:
Meniscal Injuries
Meniscal Tear
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
This multicenter, stratified, partially randomized clinical trial aims to compare autologous semitendinosus tendon graft and meniscal allograft transplantation (MAT) in young adults with post-meniscec...
Detailed Description
Post-meniscectomy syndrome represents a challenging condition in young adults, characterized by persistent pain, swelling, and functional impairment after partial or subtotal meniscectomy. The lack of...
Eligibility Criteria
Inclusion
- Adults aged 18 to 45 years
- History of partial meniscectomy \> 6 months prior to enrollment
- Symptomatic post-meniscectomy syndrome (knee pain, swelling, or functional decline)
- MRI showing cartilage status ≤ Outerbridge grade 2
- Knee joint stability (or stabilized during the index surgery)
- Body mass index (BMI) \< 30
- Willingness to provide written informed consent
Exclusion
- Tibial slope \> 16°
- Radiographic or arthroscopic evidence of advanced cartilage degeneration (Outerbridge \> 2 or ICRS ≥ 3)
- Presence of inflammatory arthritis or systemic inflammatory joint disease
- History of cartilage repair surgery
- Malalignment \> 5° not corrected
- Untreated ligamentous instability
- Any other condition judged by the investigator to compromise study participation or outcomes
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2029
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07204587
Start Date
October 1 2025
End Date
September 30 2029
Last Update
October 2 2025
Active Locations (1)
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1
Chang Gung memorial hospital, Taoyuan, taoyuan 333
Taoyuan, Taoyuan, Taiwan, 33305