Status:
NOT_YET_RECRUITING
Walking for Hypothyroidism Trial (WHT)
Lead Sponsor:
University of Karachi
Collaborating Sponsors:
Advanced Education & Research Center
Conditions:
Hypothyroidism
Eligibility:
FEMALE
35-55 years
Phase:
NA
Brief Summary
Women with hypothyroidism often report persistent fatigue, weight gain, autonomic dysregulation, and stress despite stable levothyroxine therapy. This single-center, parallel-group RCT will test wheth...
Detailed Description
This trial evaluates a pragmatic, low-cost aerobic intervention-walking 30 minutes/day, 5 days/week at 55-65% HRmax for 12 weeks-as an adjunct to standard pharmacotherapy. Expected benefits: ↑BMR, ↑HR...
Eligibility Criteria
Inclusion
- Female, aged 35-55 years
- Primary hypothyroidism with documented prior TSH \>4.5 mIU/L
- Stable levothyroxine dose for at least 6 months
- Sedentary lifestyle (\<150 minutes of moderate-vigorous activity per week)
- BMI between 20-35 kg/m²
- Able to walk unaided
- Willing and able to provide written informed consent
Exclusion
- Pregnant or lactating, or planning pregnancy during the study period
- Use of beta-blockers, systemic corticosteroids, or medications significantly affecting heart rate, HRV, or metabolism
- Uncontrolled hypertension, insulin-dependent diabetes, symptomatic cardiovascular disease, or orthopedic conditions limiting walking
- Major psychiatric hospitalization in the past 12 months
- Participation in another interventional trial within the past 30 days
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07205042
Start Date
November 1 2025
End Date
June 30 2026
Last Update
October 3 2025
Active Locations (1)
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1
University of Karachi
Karachi, Sindh, Pakistan, 78500