Status:
RECRUITING
A Clinical Trial of SIBP-A10 Injection in the Treatment of Advanced Malignant Tumor Subjects.
Lead Sponsor:
Shanghai Institute Of Biological Products
Conditions:
Advanced Tumors
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
Brief Summary
To evaluate the safety, tolerability of SIBP-A10 and determine the maximum tolerable dose (MTD) and phase II recommended dose (RP2D).
Detailed Description
This study is an open label, dose escalation, dose expansion, and indication expansion study to evaluate safety, tolerability, pharmacokinetics, preliminary anti-tumor efficacy, immunogenicity, impact...
Eligibility Criteria
Inclusion
- Voluntarily participate in this study and sign an informed consent form;
- Age range of 18 to 75 years old (including boundary values), gender not limited;
- The clinical diagnosis of enrolled subjects should meet the conditions specified in the protocol:
- There must be at least one measurable lesion as the target lesion;
- Backfilling queue during dose escalation stage, dose expansion stage, and indication expansion stage: able to provide tumor tissue samples that meet the requirements of the protocol or undergo tumor biopsy during screening, or provide testing reports issued by legitimate testing institutions that meet the requirements;
- I have not received any medication targeting Siglec-15 in the past;
- The Eastern Cooperative Oncology Group (ECOG) physical fitness score ranges from 0 to 1;
- Expected survival period ≥ 3 months;
- During the screening period, the main organ functions were basically normal;
- During the screening period, women of childbearing age had negative blood pregnancy tests, and reproductive age subjects (including male subjects) had no pregnancy plans during the trial period and within 6 months after the last dose, and voluntarily took effective contraceptive measures.
Exclusion
- The subject has the following tumors:
- The subject has had other malignant tumors that have not healed within the past 5 years;
- Subjects with meningeal metastases;
- Subjects with active brain metastases;
- For anti-tumor subjects with a history of past treatment or surgery that does not comply with the protocol, or who have received treatment that does not comply with the protocol during the planned trial period
- Previous medical history or laboratory non-compliance with protocol requirements
- According to the researchers' assessment, the screening period is accompanied by severe, progressive, or uncontrolled non-tumor diseases, and it has been determined by the researchers that participating in the study would increase the risk for the subjects.
- According to the investigator's judgment, there are concomitant diseases (including but not limited to hypertension, diabetes, active infection, etc. that cannot be controlled by drugs) that seriously endanger the patient's safety or affect the patient's completion of the study
- Researchers determine that there are uncontrollable ascites, pleural effusion, or pericardial effusion, or those who have undergone ≥ 2 serosal drainage within 2 weeks prior to the first administration;
- Before starting treatment, the patient has not yet recovered to ≤ grade 1 from the toxic effects of previous treatments (including previous immunotherapy) and/or complications of previous surgical interventions.
- Individuals with a history of severe allergies to protein products, CHO cell products, other recombinant human or humanized antibodies, or components of the investigational drug;
- Pregnant and lactating women;
- Researchers believe that subjects who are not suitable to participate in this clinical study due to other reasons.
Key Trial Info
Start Date :
October 31 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2028
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT07205198
Start Date
October 31 2025
End Date
December 30 2028
Last Update
January 8 2026
Active Locations (1)
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1
Zhongshan Hospital Affiliated to Dalian University
Dalian, Liaoning, China