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Status:

NOT_YET_RECRUITING

Aspirin for Stroke Prevention After Endovascular Aortic Arch Repair: A Multicenter, Double-Blind, Randomized Controlled Trial

Lead Sponsor:

Wei Wu

Conditions:

Type B or Non-A Non-B Aortic Dissection;Thoracic Aortic Aneurysm

Eligibility:

All Genders

18+ years

Phase:

EARLY_PHASE1

Brief Summary

Abstract Introduction: Endovascular aortic arch repair (EAAR) and endovascular reconstruction of arch branch vessels have emerged as a new trend in treating aortic arch pathologies due to their advant...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Adult patients aged 18 years or older;
  • Diagnosed with type B or non-A non-B aortic dissection or thoracic aortic aneurysm according to the 2022 Chinese Expert Consensus on Stanford Type B Aortic Dissection;
  • Underwent total endovascular aortic arch repair at the participating center with concurrent intraoperative endovascular reconstruction of supra-arch branch arteries;
  • Signed the informed consent form and agreed to participate in this randomized controlled trial.
  • Exclusion Criteria
  • Patients with known allergies to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs);
  • Patients with bleeding tendencies or active bleeding;
  • Patients who used medications affecting coagulation (e.g., warfarin, antiplatelet drugs) within 30 days before surgery;
  • Patients with a history of stroke;
  • Patients undergoing concurrent additional surgical procedures during the operation;
  • Patients with severe multi-organ dysfunction or other critical illnesses;
  • Patients unable to comply with study protocols or complete postoperative follow-up;
  • Patients participating in other drug or clinical studies that may interfere with the results of this research.

Exclusion

    Key Trial Info

    Start Date :

    October 8 2025

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    January 10 2027

    Estimated Enrollment :

    538 Patients enrolled

    Trial Details

    Trial ID

    NCT07205250

    Start Date

    October 8 2025

    End Date

    January 10 2027

    Last Update

    October 3 2025

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