Status:
COMPLETED
AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness
Lead Sponsor:
Qilu Hospital of Shandong University
Conditions:
Acute Febrile Illness
Bacterial Infections
Eligibility:
All Genders
14+ years
Brief Summary
This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754). Although both studies share the same clinical coh...
Detailed Description
This study aims to identify and validate proteomics-based diagnostic biomarkers for differentiating bacterial from viral acute febrile illnesses. It is conducted on the same patient cohort previously ...
Eligibility Criteria
Inclusion
- Age ≥14 years；
- Body temperature \> 38°C(within the past 72 hours)；
- Disease duration ≤ 14 days；
- Provision of informed consent by patient or legal guardian.
Exclusion
- Underlying diseases affecting immune function (e.g., advanced malignancy, autoimmune disease, immunodeficiency, use of immunosuppressants);
- Pregnancy;
- Mixed infections (including viral-bacterial co-infections, bacterial or viral-fungal co-infections, or autoimmune disease concomitant with bacterial infection);
- indeterminate or negative microbiological testing ;
- inability to provide informed consent
Key Trial Info
Start Date :
September 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2024
Estimated Enrollment :
394 Patients enrolled
Trial Details
Trial ID
NCT07205575
Start Date
September 1 2021
End Date
November 30 2024
Last Update
October 3 2025
Active Locations (1)
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1
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012