Status:
RECRUITING
In-depth Analysis of Cholesterol Metabolism and Related Biomarkers in the Pathogenesis and Progression of the Disease in Neurodegenerative Dementias
Lead Sponsor:
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Collaborating Sponsors:
Università di Torino, Torino
Ospedale San Luigi Gonzaga, Orbassano
Conditions:
Dementias
Neurodegenerative Dementia
Eligibility:
All Genders
40-85 years
Brief Summary
The aim of the study is to evaluate the role of cholesterol in the pathogenesis of neurodegenerative dementias. Hypercholesterolemia is a known risk factor for Alzheimer disease (AD) and oxysterols, t...
Detailed Description
The project is a monocentric retrospective and prospective low-intervention clinical study. All the samples collected will be sent for all analysis to the Laboratory of General Pathology and Pathophys...
Eligibility Criteria
Inclusion
- Age 40-85
- Diagnosis based on the current diagnostic criteria for AD (McKhann et al., 2011), FTD (Gorno-Tempini et al., 2011; Rascovsky et al., 2011), PSP and CBD (Amstrong et al., 2013; Höglinger et al., 2017)
- Mini Mental State Examination MMSE \> 10.
Exclusion
- Other neurological or psychiatric disorders Severe chronic metabolic diseases
Key Trial Info
Start Date :
June 5 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 29 2027
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07207486
Start Date
June 5 2023
End Date
April 29 2027
Last Update
October 6 2025
Active Locations (2)
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1
Università di Torino AOU San Luigi Gonzaga
Torino, to, Italy, 10043
2
Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Italy, 20133