Status:
NOT_YET_RECRUITING
tESCS for Upper Limb Rehab in Spinal Cord Injury
Lead Sponsor:
NHS Greater Glasgow and Clyde
Collaborating Sponsors:
University of Glasgow
The Queen Elizabeth Hospital
Conditions:
Spinal Cord Injuries (SCI)
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Regaining hand and arm function is an important step towards regaining independence following high-level spinal cord injury (tetraplegia). The delivery of small electrical pulses over the skin above t...
Detailed Description
Background Spinal Cord Injury affects more than 50,000 people in the UK, with an incidence of 2400 new cases every year. Muscular paralysis and sensory loss carry substantial physiological, psychologi...
Eligibility Criteria
Inclusion
- Aged 18 years or over, both sexes.
- At least 6 weeks post-implant (in participants having a surgery for an implant to stabilise the spine).
- ISNCSCI upper extremity motor score between 5 and 30 (both arms/hands)
- GRASSP-strength score \>=15 \& \<70
- Medically stable, cognitively intact and able to breathe independently.
- Attending upper limb therapy sessions at the QENSIU
- Planned stay longer than the duration of the intervention
- Able to sit for more than 2 hours a day
Exclusion
- Unstable cervical spine injury
- Needing ventilation assistance during daytime
- Any implanted active metallic device without unconfirmed MRI compatibility (in our previous studies, we safely applied tESCS to participants with MRI-compatible devices/implants)
- Pregnancy and/or lactation.
- Non-injury-related neurological impairment
- Severe spasticity which have been unstable prior to enrolment
- Botulinum toxin injections-
- Clinically significant severe depression
- Patients who have cardiovascular disease
- Patients with severe ongoing Autonomic Dysreflexia
- Skin conditions or allergies that may affect electrode placement.
- Current infections
- Patients who have been involved in any other interventional study
Key Trial Info
Start Date :
November 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07208188
Start Date
November 1 2025
End Date
December 1 2027
Last Update
October 6 2025
Active Locations (1)
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1
Queen Elizabeth National Spinal Injuries Unit
Glasgow, United Kingdom, G51 4TF