Status:
NOT_YET_RECRUITING
Texture and Colour Enhancement Imaging (TXI) Versus Dye Chromoendoscopy for Dysplasia Detection in IBD Surveillance.
Lead Sponsor:
London North West Healthcare NHS Trust
Conditions:
IBD
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In individuals with inflammatory bowel disease (IBD), bowel cancer can develop from abnormal cell changes (dysplasia). Regular colonoscopies are recommended to identify these early changes, which can ...
Detailed Description
Bowel cancer in individuals with inflammatory bowel disease (IBD) often develops from abnormal changes in the cells lining the bowel, known as dysplasia. International guidelines recommend undertaking...
Eligibility Criteria
Inclusion
- Patients \>16 with inflammatory bowel disease undergoing surveillance colonoscopy.
- Patients with Crohn's (L2/L3 Montreal classification) with \>50% colonic involvement
- Patients with ulcerative colitis with Extensive or left sided disease (E3 or E2 Montreal classification) for at least 8 years or a diagnosis of Primary sclerosing cholangitis concomitant with IBD.
Exclusion
- The participant may not enter the study if ANY of the following apply:
- Disease duration \<8 years unless a diagnosis of PSC
- Incomplete colonoscopy
- BBPS \<6 or \<2 in any segment
- MES ≥2 or any variable of the SES-CD is ≥2 or any stenosis for \>10cm segment (above the rectum)
- Previous colorectal resection
- Thrombocytopaenia (platelet count \<50) or Coagulopathy precluding biopsy
- Anticoagulation that has not been held appropriately prior to the procedure (must be held at least the morning of the procedure).
- Allergy to Indigo Carmine
- Pregnancy
- Unable or unwilling to consent to study participation
Key Trial Info
Start Date :
October 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
242 Patients enrolled
Trial Details
Trial ID
NCT07208214
Start Date
October 1 2025
End Date
July 1 2027
Last Update
October 6 2025
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