Status:
RECRUITING
Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures
Lead Sponsor:
Nishtar Medical University
Conditions:
Mandible Fracture
Edema Face
Eligibility:
All Genders
18-40 years
Phase:
PHASE2
Brief Summary
The rationale of the current research is to address the limitation of existing knowledge as it is not clear which of the two drugs (Dexamethasone or Methylprednisolone) is more effective in reduction ...
Detailed Description
Corticosteroids such as dexamethasone and methylprednisolone have been widely investigated in oral and maxillofacial surgery for their ability to reduce postoperative pain, edema, and trismus. Several...
Eligibility Criteria
Inclusion
- Patients aged 18 to 40.
- Both Gender.
- Fracture less than a week old.
- Isolated mandibular parasymphysis fractures.
Exclusion
- 1\. Immunocompromised patients (due to increased risk of infection and complications).
- 2\. Patients experiencing acute pain from conditions such as pulpitis, abscesses, or other acute infections (to ensure that acute pain does not confound the study results).
- 3\. Patients reporting hypersensitivity to steroids (to avoid adverse reactions).
- 4\. Patients taking or requiring prophylactic antibiotics or anti-inflammatory drugs before surgery (to prevent confounding effects on study outcomes).
- 5\. Patients with a history of systemic steroid administration for 15 days (as this could affect the study's outcomes).
- 6\. Patients with chronic pain problems or mental disorders (to maintain consistency in response to treatment).
- 7\. Patients with comminuted fractures (to maintain consistency in fracture type).
- 8\. Pregnant or lactating women (to avoid potential risks to the fetus and nursing infant).
- 9\. Smokers who smoke at least 10 cigarettes per day for 2 years (to minimize the impact of smoking on healing and recovery).
- ria:
Key Trial Info
Start Date :
January 3 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT07208799
Start Date
January 3 2026
End Date
December 1 2026
Last Update
January 6 2026
Active Locations (1)
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1
Nishtar Institute of Dentistry Multan
Multan, Punjab Province, Pakistan, 60000