Status:
RECRUITING
A Clinical Study of MK-1084 in People With Advanced Solid Tumors (MK-1084-014)
Lead Sponsor:
Merck Sharp & Dohme LLC
Conditions:
Neoplasm Malignant
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Researchers want to learn if MK-1084 given alone or with cetuximab can treat certain advanced solid tumors in people with the KRAS G12C mutation. The goals of this study are to learn: * How many peo...
Eligibility Criteria
Inclusion
- The main inclusion criteria include but are not limited to the following:
- Has locally advanced unresectable or metastatic solid tumor malignancy other than colorectal cancer and has progressed on, or following, standard of care systemic treatment
- Has a tumor that demonstrates the presence of Kirsten rat sarcoma (KRAS) G12C mutation
Exclusion
- The main exclusion criteria include but are not limited to the following:
- Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
- Has known additional malignancy that is progressing or has required active treatment within the past 3 years
- Has known active central nervous system metastases and/or carcinomatous meningitis and/or primary brain tumors
- Has active infection, other than those permitted per protocol, requiring systemic therapy
- Has not adequately recovered from major surgery or has ongoing surgical complications
Key Trial Info
Start Date :
December 4 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 9 2032
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT07209111
Start Date
December 4 2025
End Date
April 9 2032
Last Update
January 5 2026
Active Locations (14)
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1
Greater Baltimore Medical Center ( Site 1104)
Baltimore, Maryland, United States, 21204
2
START Midwest ( Site 1103)
Grand Rapids, Michigan, United States, 49546
3
START Mountain Region ( Site 1106)
West Valley City, Utah, United States, 84119
4
Odense Universitetshospital ( Site 1401)
Odense, Region Syddanmark, Denmark, 5000