Status:
NOT_YET_RECRUITING
Temporal Interference Methods for Addiction Treatment
Lead Sponsor:
Indiana University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Nicotine Use Disorder
Substance Use Disorders
Eligibility:
All Genders
21-50 years
Phase:
NA
Brief Summary
This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape. TI delivers mild elect...
Detailed Description
Substance use disorders (SUDs) are difficult to treat effectively, with high relapse rates despite behavioral and pharmacological interventions. Previous clinical and case studies have shown that dire...
Eligibility Criteria
Inclusion
- Between the ages of 21 and 50
- Nicotine dependent and vape at least 15 mg nicotine per day
- Must have a phone with internet access
- Participants must have at least a 6th grade education and be able to speak and read English
Exclusion
- History of seizures, seizure disorders, or familial history of seizure disorders
- History of intractable migraine or complicated migraine syndromes
- History of suicide attempts or active suicidal ideation (past month)
- History of cardiac arrhythmias, prolonged QT, pacemakers, or cardiovascular disorders
- Hypertension with systolic BP \>150mmHgCentral nervous system structural lesions (tumors, MS, strokes, etc.)
- Active neuropsychiatric disorders (schizophrenia, bipolar, active psychosis, dementia, etc.)
- History of head trauma with loss of consciousness, skull fractures, subdural hematomas
- Active opioid, cocaine, and/or methamphetamine use
- Active severe cannabis use disorder
- Active alcohol use disorder or history of alcohol withdrawal
- Metal implants in the head or under the scalp (excluding dental implants)
- Current smoking cessation treatment or medications affecting reward processing
- Pregnancy
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 27 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07210268
Start Date
December 1 2025
End Date
February 27 2026
Last Update
December 3 2025
Active Locations (1)
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1
Indiana University
Bloomington, Indiana, United States, 47403