Status:
ACTIVE_NOT_RECRUITING
Early Predictors for Neurological Outcome After Traumatic Spinal Cord Injury
Lead Sponsor:
BG Unfallklinik Murnau
Collaborating Sponsors:
Foundation Wings For Life
University of California, San Francisco
Conditions:
Acute Traumatic Spinal Cord Injury
Eligibility:
All Genders
18+ years
Brief Summary
This project investigates early predictors of neurological recovery after traumatic spinal cord injury through three main aims: 1. MAP and vasopressors - determine whether continuous monitoring of me...
Detailed Description
Study rationale In order to address the question whether MAP targets and pharmacological interventions affect the neurological outcome after traumatic SCI, a large sample size of longitudinal data is ...
Eligibility Criteria
Inclusion
- General
- Data from patients who sustained traumatic SCI, and who
- completed at least one neurological examination in the acute / sub-acute stage of injury (between the day of injury and 40 days post-SCI) and in the chronic stage of injury (the latest neurological assessment between day 70 and day 546 after SCI)
- agreed to provide their medical data for research purposes in the European Multicenter Study about Spinal Cord Injury (EMSCI) database
- specific for Cohort 1: MAP Cohort patients who
- were initially admitted to the BG Trauma Center Murnau, or transferred for acute SCI care within two days after trauma
- were treated in the intensive care unit (ICU) and underwent hemodynamic monitoring for at least 24 hours
- specific for Cohort 2: Biomarker Cohort - patients who had at least five blood samples collected within the first year after injury, with the first sample obtained within two weeks post-injury
- specific for Cohort 3: Opioid Cohort
- \- patients who were treated in the ICU and received opioid therapy, including detailed information on timing, dosage, and duration of administration
Exclusion
- Patients with non-traumatic spinal cord injury or non-spinal cord injury
- Patients who were initially admitted and/or surgically treated in another hospital and transferred to the BG Trauma Center Murnau later than two days post-SCI
Key Trial Info
Start Date :
July 20 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 30 2026
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT07210879
Start Date
July 20 2022
End Date
August 30 2026
Last Update
October 7 2025
Active Locations (1)
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1
BG Trauma Center Murnau
Murnau am Staffelsee, Bavaria, Germany, 82418