Status:
NOT_YET_RECRUITING
Improving the Treatment of Depression Among Youth With HIV
Lead Sponsor:
Rhode Island Hospital
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Depression Disorders
HIV (Human Immunodeficiency Virus)
Eligibility:
All Genders
15-24 years
Phase:
NA
Brief Summary
Depression is a common psychiatric condition among Youth with HIV (YWH), with prevalence as high as 25% in the United States. The treatment of depression is essential for improving both psychiatric an...
Detailed Description
Depression is a common psychiatric condition among Youth with HIV (YWH), with prevalence as high as 25% in the United States. The treatment of depression is essential for improving both psychiatric an...
Eligibility Criteria
Inclusion
- aged 15- 24 years
- engaged in care at a participating HIV care site
- have documented HIV-1 confirmed by medical records
- a diagnosis as determined by a site clinician of nonpsychotic depression requiring treatment \[either Major Depressive Disorder (MDD), Depression not otherwise specified, or Dysthymia as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-V)
- significant symptomatology at Entry (as defined by the PHQ-9)
- aware of their HIV status as determined by site staff
- English-speaking
- able and willing to provide written informed assent/consent and written parental or guardian permission
Exclusion
- by site review, have a history of any psychotic disorders and/or Bipolar I or II Disorder
- have of a severe alcohol or substance dependence according to DSM-V or had moderate symptoms and are experiencing withdrawal or dependence symptoms within the month prior to enrollment
- have depression and/or suicidal ideation requiring more intensive services
- intend to relocate from the study site; 5) are in therapy with a non-study therapist (unless willing to switch to a study-trained therapist)
- if they are in imminent danger to themselves or others. If wards of the state meet all eligibility requirements, they will be eligible if the state allows them to participate in research. Otherwise, they will be excluded.
Key Trial Info
Start Date :
April 15 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2030
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT07211087
Start Date
April 15 2026
End Date
March 31 2030
Last Update
October 7 2025
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