Status:
NOT_YET_RECRUITING
The Role of Estrogen and Testosterone in Determining Heart, Lung, and Brain Regulation in Humans
Lead Sponsor:
University of British Columbia
Conditions:
Cerebral Blood Flow
Cerebral Blood Flow Regulation
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many d...
Detailed Description
Aim 1: Women have historically been excluded from research due to sociocultural and gender biases from a lack of understanding of the menstrual cycle and hormone levels. As a result, many diagnoses an...
Eligibility Criteria
Inclusion
- The investigators will recruit healthy young (18-40 years) males (n = 25) and females (n = 25). Females must be naturally cycling (i.e., no oral or hormonal contraceptives), not pregnant, and premenopausal. Participants must be normotensive (\<140/90 mmHg \& \>90/60 mmHg) and have no medical history of cerebrovascular, cardiopulmonary, cardiovascular, neuromuscular, and renal disease assessed by a study questionnaire. All subjects will sign an informed consent form prior to participation.
Exclusion
- Participants will be excluded if they are hypertensive or hypotensive, have any history of cerebrovascular, cardiopulmonary, cardiovascular, neuromuscular, or renal disease, are smokers, or take cardiovascular medications. Individuals with a current eating disorder (\>2 on the 'SCOFF' questionnaire 68 will also be excluded. Females will be excluded if they have an irregular menstrual cycle, any medical conditions that may affect the menstrual cycle, are pregnant, breastfeeding, or planning to conceive within 3 months, or use oral or hormonal birth control (Copper intrauterine devices (IUDs) will be allowed as they do not change systemic hormone levels). Participants who have had brain surgery, have or think they may have epilepsy, have a family history of epilepsy, or have had a recent (\< 6 months) head injury or concussion would be excluded from the portion of the study that involves transcranial magnetic stimulation (TMS).
Key Trial Info
Start Date :
March 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT07212712
Start Date
March 1 2026
End Date
December 31 2027
Last Update
October 8 2025
Active Locations (1)
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1
University of British Columbia - Okanagan
Kelowna, British Columbia, Canada, V1V 1V7