Status:
RECRUITING
Follicular Fluid microRNAs in Ovarian Aging and Reproduction
Lead Sponsor:
University of Central Florida
Collaborating Sponsors:
The IVF Center at Winter Park
Conditions:
Ovarian Aging
In Vitro Fertilisation (IVF) Treatment
Eligibility:
FEMALE
18+ years
Brief Summary
The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes. The...
Detailed Description
There is a substantial gap in understanding how these miRNAs operate in humans, especially in a non-invasive or minimally invasive context. Specifically: * The role of exosomal miRNAs in follicular ...
Eligibility Criteria
Inclusion
- Women undergoing IVF treatment due to male factor infertility or nonovarian causes.
- Age groups: younger women \<31 years and older women \>38 years.
- Regular menstrual cycles.
- Willing and able to provide informed consent.
Exclusion
- Minors (under 18 years) and women aged 32-37 years
- Diagnosis of polycystic ovarian syndrome (PCOS).
- History of recurrent pregnancy loss.
- Presence of endometriosis.
- Diagnosis of ovarian insufficiency.
- Metabolic disorders (e.g., diabetes).
- History of ovarian surgery or chemotherapy.
- Any condition that might impact follicular fluid quality or IVF outcomes.
Key Trial Info
Start Date :
September 22 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT07214246
Start Date
September 22 2025
End Date
September 1 2026
Last Update
October 9 2025
Active Locations (1)
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1
University of Central Florida
Orlando, Florida, United States, 32827