Status:
RECRUITING
Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude
Lead Sponsor:
Embry-Riddle Aeronautical University
Conditions:
Healthy Adults
Mechanical Ventilation Dependence
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced o...
Detailed Description
This study is designed to test whether two non-drug interventions-respiratory muscle training (RMT) and dietary nitrate supplementation-can improve exercise performance and tolerance when oxygen level...
Eligibility Criteria
Inclusion
- Healthy adults between 18 and 40 years old.
- Recreationally active (performing ≥3 hours of structured physical activity per week).
- Non-smokers for at least the past 6 months.
- Free from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.
- Able to perform cycle ergometer exercise to volitional fatigue.
- Willing to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.
- Able and willing to provide written informed consent and comply with all study procedures.
Exclusion
- Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).
- Current use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).
- Smoking, vaping, or tobacco use within the past 6 months.
- Known allergy or intolerance to beetroot products or nitrates.
- Participation in another interventional research study within the past 30 days.
- Pregnant or breastfeeding women.
- Any orthopedic or musculoskeletal limitation preventing safe exercise testing.
- Failure to meet inclusion criteria or inability to complete familiarization and baseline testing.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2028
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07216755
Start Date
September 1 2025
End Date
August 31 2028
Last Update
October 15 2025
Active Locations (1)
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1
Embry-Riddle Aeronautical University
Daytona Beach, Florida, United States, 32114