Status:
RECRUITING
Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years
Lead Sponsor:
Case Western Reserve University
Collaborating Sponsors:
National Eye Institute (NEI)
Conditions:
Fuchs Endothelial Corneal Dystrophy
Corneal Endothelial Decompensation
Eligibility:
All Genders
30-93 years
Phase:
NA
Brief Summary
This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endotheli...
Eligibility Criteria
Inclusion
- Willing to return to the study site for follow up at 3 and 5 years after a Descemet membrane endothelial keratoplasty procedure
- Fluent in English or Spanish
- Willing to have fingerstick blood sample collected to determine HbA1c level
- Participated and completed 12-month follow-up in the DEKS study for one or both eyes or a DEKS participant that had a study eye regraft prior to the 12-month visit.
Exclusion
- Lack cognitive capacity such that consent could not be provided.
Key Trial Info
Start Date :
December 3 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2030
Estimated Enrollment :
570 Patients enrolled
Trial Details
Trial ID
NCT07217249
Start Date
December 3 2025
End Date
April 30 2030
Last Update
December 16 2025
Active Locations (5)
Enter a location and click search to find clinical trials sorted by distance.
1
Price Vision Group
Indianapolis, Indiana, United States, 46260
2
University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States, 52242
3
University of Michigan/Kellogg Eye Center
Ann Arbor, Michigan, United States, 48105
4
Verdier Eye Center
Grand Rapids, Michigan, United States, 49546