Status:
NOT_YET_RECRUITING
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
Lead Sponsor:
Kai Hwang
Conditions:
Schizophrenia
Attention Deficit Disorder With Hyperactivity (ADHD)
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) t...
Detailed Description
The human brain's ability to learn and execute behaviors tailored to environmental contingencies is crucial for adaptive cognition. Central to this capacity are neural representations of context, whic...
Eligibility Criteria
Inclusion
- No history of any neurological, psychiatric, or medical condition that could affect cognition
- No use of benzodiazepines, long-acting opioids, or other psychotropic drugs that could alter cognitive performance
- Normal or corrected-to-normal vision (visual acuity)
- Normal color perception (Farnsworth-Munsell 100 Hue Test)
- Fluent in English
- No metal implants (including aneurysm clip, cardiac pacemaker, ICD, IUD, neurostimulation system, spinal cord stimulator, internal electrodes or wires, bone stimulator, ear implant, insulin or other infusion pump or device, prosthesis, artificial or prosthetic limb, shunt, vascular access port or catheter, thermodilution catheter, medication patch, radiation seeds or implants, wire mesh implant, tissue expander, surgical staples or clips or sutures, joint replacement, joint/bone pin/screw/nail/wire/plate, dentures, or non-removable hearing aid)
- No exposure to shrapnel or other-related MR contraindications
- No non-removable body piercing jewelry
- No non-removable makeup
- No history of claustrophobia
- No history of breathing problems
- Not currently pregnant or trying to get pregnant (this will be determined via self report and no records will be kept).
Exclusion
- Has a history of any neurological, psychiatric, or medical condition that could affect cognition
- Use of benzodiazepines, long-acting opioids, or other psychotropic drugs that could alter cognitive performance
- Not fluent in English
- Known metal implants (including aneurysm clip, cardiac pacemaker, ICD, IUD, neurostimulation system, spinal cord stimulator, internal electrodes or wires, bone stimulator, ear implant, insulin or other infusion pump or device, prosthesis, artificial or prosthetic limb, shunt, vascular access port or catheter, thermodilution catheter, medication patch, radiation seeds or implants, wire mesh implant, tissue expander, surgical staples or clips or sutures, joint replacement, joint/bone pin/screw/nail/wire/plate, dentures, or non-removable hearing aid)
- History of claustrophobia
- Currently pregnant or trying to get pregnant (this will be determined via self report and no records will be kept).
Key Trial Info
Start Date :
December 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2030
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT07217652
Start Date
December 1 2025
End Date
July 30 2030
Last Update
October 16 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The University of Iowa
Iowa City, Iowa, United States, 52242