Status:
RECRUITING
Single Shot Exparel vs Catheters in Lower Extremity Trauma
Lead Sponsor:
George Washington University
Conditions:
Fracture Dislocation of Ankle Joint
Fracture Leg
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine. The ...
Detailed Description
The use of Exparel has been widely criticized over the past few years with regard to its efficacy compared to perineural catheters and whether or not it truly lasts 72 hours, as is often advertised. H...
Eligibility Criteria
Inclusion
- Closed lower extremity orthopedic injury
- Opioid naive patients
- No other significant surgical injuries on admission as determined by study physician
Exclusion
- Allergy to local anesthetics
- Multiple traumatic injuries
- Weight less than 60 kg
- Prior opioid use or risk of increased pain control needs as determined by PI
- Chronic opioid use
- Open fractures
- Plastic surgery needed for complete closure
- Patient has intraoperative cardiac arrest
Key Trial Info
Start Date :
September 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 11 2029
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT07221019
Start Date
September 12 2025
End Date
August 11 2029
Last Update
October 28 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The George Washington University Hospital
Washington D.C., District of Columbia, United States, 20037