Status:

ACTIVE_NOT_RECRUITING

A Study to Learn About Different Dosing Schedules of a Lyme Disease Vaccine in Healthy Adults

Lead Sponsor:

Pfizer

Conditions:

Lyme Borreliosis

Eligibility:

All Genders

18-44 years

Phase:

PHASE3

Brief Summary

The purpose of this study is to learn about the safety and effects of the Lyme disease vaccine (called VLA15) when given at different time points. This study is seeking participants who: * are gener...

Detailed Description

This is a Phase 3, randomized, parallel-group, placebo-controlled, double-blinded (third-party unblinded) study to evaluate the safety, tolerability, and immunogenicity of different vaccination schedu...

Eligibility Criteria

Inclusion Criteria:

  • Participants who are healthy as determined by medical history and clinical judgment.
  • Participants willing and able to comply with all scheduled visits, IP receipt, and other procedures throughout the study.
  • Able to provide Informed Consent.

Exclusion Criteria:

  • Pregnant or breastfeeding participants.
  • Allergies or contraindications to vaccines or their components.
  • Health issues including: blood clotting deficiencies, immunodeficiencies, bone marrow disorder, or uncontrolled psychiatric conditions.
  • Receipt of therapies to treat malignancies, blood/plasma products and immunoglobulins, systemic corticosteroids and immunosuppressants, or anticoagulant therapy in recent medical history.
  • Any prior Lyme disease vaccination, or recent or concurrent participation in a separate interventional study.
  • Staff or direct family of the study site staff and Sponsor.

Key Trial Info

Start Date :

November 19 2025

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

January 27 2028

Estimated Enrollment :

207 Patients enrolled

Trial Details

Trial ID

NCT07226882

Start Date

November 19 2025

End Date

January 27 2028

Last Update

April 17 2026

Active Locations (10)

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Page 1 of 3 (10 locations)

1

University of Massachusetts Chan Medical School

Worcester, Massachusetts, United States, 01655

2

IMA Clinical Research Warren

Warren Township, New Jersey, United States, 07059

3

Smith Allergy and Asthma Specialists

Cortland, New York, United States, 13045

4

Smith Allergy & Asthma Specialists

Horseheads, New York, United States, 14845