Status:
RECRUITING
A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
Lead Sponsor:
Eli Lilly and Company
Conditions:
Obesity
Overweight
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of retatrutide compared with placebo for body weight reduction. Participation in the study will last about 65 weeks and may include ab...
Eligibility Criteria
Inclusion
- Have a body mass index (BMI) of:
- ≥30 kilogram per square meter (kg/m2) OR
- ≥27 kg/m2 with at least one of the following weight-related conditions: high blood pressure, abnormal levels of lipid, obstructive sleep apnea, heart disease
- Have at least one unsuccessful attempt to lose weight by dieting
Exclusion
- Have a self-reported change in body weight \>5 kg (11 pounds) within 90 days before screening
- Have a prior or planned surgical treatment for obesity
- Have type 1 diabetes or type 2 diabetes
- Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- Have had within the past 90 days before screening
- acute myocardial infarction
- cerebrovascular accident (stroke)
- hospitalization for unstable angina, or
- hospitalization due to congestive heart failure
- Have New York Heart Association Functional Classification Class IV congestive heart failure
- Have a history of chronic or acute pancreatitis
- Have taken weight loss drugs, including over-the counter medications within 90 days prior to screening
Key Trial Info
Start Date :
November 17 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT07232719
Start Date
November 17 2025
End Date
July 1 2027
Last Update
January 6 2026
Active Locations (31)
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1
Artemis Institute for Clinical Research
Riverside, California, United States, 92503
2
JEM Research Institute
Atlantis, Florida, United States, 33462
3
Headlands Research Orlando
Orlando, Florida, United States, 32806
4
Care Access - Tamarac
Tamarac, Florida, United States, 33321