Inclusion Criteria:

• Biological sex: female
• Age: 40-60 years
• Self-determined decision to participate, confirmed by signing the informed consent form (ICF)
• Fluent in German
• Agreement to wear a smartwatch (Garmin Vivosmart 5) for most of the time over six months
• Ownership of a smartphone compatible with the Fitrockr application
• Confirmed post-menopausal status: Spontaneous amenorrhea for ≥12 consecutive months without other causes OR ≥6 months of spontaneous amenorrhea with biochemical confirmation (FSH > 40 IU/L OR FSH > 30 IU/L for women aged ≥50 using hormonal contraception) OR bilateral oophorectomy ≥6 weeks before enrollment

Exclusion Criteria:

• Inability to provide informed consent
• Known allergic reaction to polycarbonate (smartwatch wristband material)
• Asthma not well-controlled (ACT score <20 despite medication)
• Use of injectable asthma drugs with broad immunomodulatory activity
• Coronary artery disease
• Diagnosis of diabetes mellitus
• Cancer diagnosis
• Diagnosis of chronic kidney disease
• Confirmed diagnosis of familial hypercholesterolemia (genetic)
• Sleep apnea managed with bi-level positive airway pressure (PAP)
• Chronic rhinosinusitis
• Severe (stage 3 or 4) chronic obstructive pulmonary disease (COPD) or interstitial lung disease with hospitalization within the prior 12 months for respiratory symptoms
• Any other condition/treatment deemed incompatible with the study objectives by the PI or delegated co-investigators
• Current employment in the Section of Gynecological Endocrinology and Reproductive Medicine (Inselspital Bern) or any other relation to the principal investigator
• Concurrent participation in a clinical interventional study
• Technical inability to pair the participant's smartphone with the smartwatch
• Inability to comply with study procedures (e.g., due to language, psychiatric illness, or inability to attend study site)