Status:
RECRUITING
ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis
Lead Sponsor:
argenx
Conditions:
Myasthenia Gravis
MG
Eligibility:
All Genders
18+ years
Brief Summary
ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to re...
Detailed Description
This is a platform study and is governed by a single master protocol that enables multiple regimens to be evaluated in separate intervention-specific appendixes (ISAs). The key design structure of th...
Eligibility Criteria
Inclusion Criteria:
- Is at least 18 years of age and the local legal age of consent for clinical studies
- Has been diagnosed with MG with consistent clinical features per the investigator's clinical judgment
- If receiving MG therapy, including nonsteroidal immunosuppressive drugs (NSIDs), corticosteroids, or acetylcholinesterase (AChE) inhibitors either in combination or alone, the participant should receive a stable dosage before master protocol screening
Exclusion Criteria:
- Known autoimmune disease or any medical condition other than the indication under study that would interfere with an accurate assessment of clinical symptoms of MG or puts the participant at undue risk
- Is MGFA (Myasthenia Gravis Foundation of America) Class V
Key Trial Info
Start Date :
December 19 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 7 2028
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT07294170
Start Date
December 19 2025
End Date
March 7 2028
Last Update
February 18 2026
Active Locations (5)
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1
Profound Research LLC - Carlsbad
Carlsbad, California, United States, 92011
2
Visionary Investigators Network
Miami, Florida, United States, 33133
3
Erlanger Health System
Columbia, Maryland, United States, 21044
4
Dent Neurologic Institute - Amherst
Amherst, New York, United States, 14226