Status:

RECRUITING

⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure

Lead Sponsor:

University of Coimbra

Collaborating Sponsors:

Unidade Local de Saúde de Coimbra, EPE

Conditions:

Myocardial Fibrosis

Heart Failure

Eligibility:

All Genders

18+ years

Brief Summary

Heart failure (HF) is a clinical syndrome with increasing incidence and prevalence, associated with high morbidity, mortality, and economic impact, despite therapeutic advances. Myocardial fibrosis i...

Eligibility Criteria

Inclusion Criteria:

  • ≥ 18 years old;
  • Signs and symptoms of heart failure (HF);
  • [Preserved left ventricular ejection fraction (LVEF) (≥50%) and Evidence of structural/functional abnormality consistent with diastolic dysfunction/increased ventricular filling pressures, including elevated natriuretic peptides and Imaging diagnosis of hypertrophic cardiomyopathy and Genetic diagnosis of hypertrophic cardiomyopathy due to sarcomeric gene mutation] OR [Reduced LVEF (≤40%) and Imaging diagnosis of dilated cardiomyopathy: left ventricular end-diastolic diameter >58 mm in men and >52 mm in women, and left ventricular volume ≥75 mL/m² in men and ≥62 mL/m² in women, not explained solely by loading conditions]
  • Recent transthoracic echocardiogram (< 3 months);
  • Recent cardiac magnetic resonance imaging (< 3 months).
  • Normal coronary angiogram or computed tomography coronary angiography within 6 months of enrolment

Exclusion Criteria:

  • Inability to provide informed consent;
  • Inability to tolerate the supine position;
  • Hemodynamic instability;
  • Claustrophobia;
  • Chronic kidney disease with glomerular filtration rate <30 mL/min/1.73m²;
  • Pregnant or breastfeeding women;
  • Malignant neoplasms within the past 5 years;
  • Significant primary valvular disease;
  • Significant atherosclerotic coronary artery disease;
  • Grade 2 or 3 arterial hypertension;
  • Presence of an implanted cardiac electrical device;
  • Recent hospitalization for heart failure (<30 days).

Key Trial Info

Start Date :

November 17 2025

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

December 31 2028

Estimated Enrollment :

30 Patients enrolled

Trial Details

Trial ID

NCT07296081

Start Date

November 17 2025

End Date

December 31 2028

Last Update

December 29 2025

Active Locations (1)

Enter a location and click search to find clinical trials sorted by distance.

Page 1 of 1 (1 locations)

1

Faculdade de Medicina da Universidade de Coimbra

Coimbra, Coimbra District, Portugal, 3000-548

⁶⁸Ga-FAPI PET/CT for Cardiac Fibrosis in Heart Failure | DecenTrialz