Status:

RECRUITING

Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound

Lead Sponsor:

Università degli Studi del Piemonte Orientale Amedeo Avogadro

Conditions:

Hydrostatic Pulmonary Edema

Acute Respiratory Failure

Eligibility:

All Genders

18+ years

Brief Summary

Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema. Rapid differentiation between cardiogenic and non-cardiog...

Detailed Description

Acute heart failure is a leading cause of emergency department visits and hospital admissions and is associated with high morbidity, mortality, and healthcare costs. Dyspnea is the most frequent prese...

Eligibility Criteria

Inclusion Criteria:

  • Adults aged ≥18 years.

  • Presentation to the emergency department with acute dyspnea and acute respiratory failure, defined by at least one of the following:

    • PaO₂ < 60 mmHg on room air, or
    • Oxygen saturation (SpO₂) < 90% on room air, or
    • PaO₂/FiO₂ ratio < 300.
  • Ability to provide written informed consent or eligibility for deferred consent according to local regulations.

  • Undergoing standard diagnostic evaluation including laboratory tests and chest imaging as part of routine clinical care.

Exclusion Criteria:

  • Refusal to provide informed consent (or consent by legal representative when applicable).
  • Inadequate ultrasound window or technically insufficient ultrasound assessment.
  • Acute respiratory failure secondary to chest trauma.
  • Cardiac arrest at presentation or during emergency department stabilization.
  • Requirement for invasive mechanical ventilation during initial stabilization in the emergency department.

Key Trial Info

Start Date :

November 1 2025

Trial Type :

OBSERVATIONAL

Allocation :

ESTIMATED

End Date :

November 1 2028

Estimated Enrollment :

200 Patients enrolled

Trial Details

Trial ID

NCT07324980

Start Date

November 1 2025

End Date

November 1 2028

Last Update

January 8 2026

Active Locations (1)

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1

Azienda Ospedaliero-Universitaria Maggiore della Carità

Novara, Italy, 28100