Status:
RECRUITING
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Lead Sponsor:
Università degli Studi del Piemonte Orientale Amedeo Avogadro
Conditions:
Hydrostatic Pulmonary Edema
Acute Respiratory Failure
Eligibility:
All Genders
18+ years
Brief Summary
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema. Rapid differentiation between cardiogenic and non-cardiog...
Detailed Description
Acute heart failure is a leading cause of emergency department visits and hospital admissions and is associated with high morbidity, mortality, and healthcare costs. Dyspnea is the most frequent prese...
Eligibility Criteria
Inclusion Criteria:
-
Adults aged ≥18 years.
-
Presentation to the emergency department with acute dyspnea and acute respiratory failure, defined by at least one of the following:
- PaO₂ < 60 mmHg on room air, or
- Oxygen saturation (SpO₂) < 90% on room air, or
- PaO₂/FiO₂ ratio < 300.
-
Ability to provide written informed consent or eligibility for deferred consent according to local regulations.
-
Undergoing standard diagnostic evaluation including laboratory tests and chest imaging as part of routine clinical care.
Exclusion Criteria:
- Refusal to provide informed consent (or consent by legal representative when applicable).
- Inadequate ultrasound window or technically insufficient ultrasound assessment.
- Acute respiratory failure secondary to chest trauma.
- Cardiac arrest at presentation or during emergency department stabilization.
- Requirement for invasive mechanical ventilation during initial stabilization in the emergency department.
Key Trial Info
Start Date :
November 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2028
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07324980
Start Date
November 1 2025
End Date
November 1 2028
Last Update
January 8 2026
Active Locations (1)
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1
Azienda Ospedaliero-Universitaria Maggiore della Carità
Novara, Italy, 28100