Inclusion Criteria:

• Adult (≥ 18 years) and has provided written informed consent.

• Confirmed diagnosis of HFE-HH in medical history.

• Evidence of iron overload as shown by:

  • TSAT > 45% (confirmed at 2 visits, at least 14 days apart) at Screening; and
  • Serum ferritin ≥ 200 nanogram per milliliter (ng/mL) and < 5000 ng/mL (confirmed at 2 visits, at least 14 days apart) at Screening; and
  • MRI-based LIC between 3 and 16 mg/g (53.7 and 286.5 millimol per kilogram [mmol/kg]) dry weight (dw) at Screening.

• Body mass index between 18.5 and 32 kilograms per meter squared (kg/m^2).

Exclusion Criteria:

• Clinically relevant laboratory abnormalities, 12-lead electrocardiogram (ECG) findings, or medical history.