Status:
COMPLETED
Association Between Autonomic Dysfunction and Choroidal Vascularity Index in Fibromyalgia
Lead Sponsor:
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Conditions:
Fibromyalgia
Autonomic Dysfunction
Eligibility:
All Genders
18-50 years
Brief Summary
Fibromyalgia is frequently accompanied by autonomic nervous system dysfunction, often characterized by sympathetic predominance. Alterations in ocular microcirculation have been reported in the presen...
Detailed Description
This is a cross-sectional, observational case-control study planned to investigate the relationship between autonomic nervous system dysfunction and choroidal vascularity index (CVI) in patients diagn...
Eligibility Criteria
Inclusion Criteria:
- Age 18-50 years, female or male
- Fibromyalgia group: diagnosis of fibromyalgia according to 2016 ACR criteria
- Ability and willingness to provide written informed consent
- Adequate ocular media clarity suitable for OCT imaging
- Control group: age- and sex-matched healthy volunteers
Exclusion Criteria:
- Ocular exclusions: cataract or other media opacity; glaucoma or optic nerve disease; ocular surface disorders (e.g., dry eye disease); retinal diseases (e.g., diabetic retinopathy, macular disease); ocular surgery or eye/head trauma within the last 3 months; best-corrected visual acuity < 20/20; refractive error > ±3.00 diopters; intraocular pressure > 21 mmHg; use of topical ophthalmic medications
- Systemic/neurologic exclusions: diabetes mellitus; hypertension; hyperlipidemia; thyroid disorders; inflammatory rheumatic/autoimmune diseases; polyneuropathy or neurodegenerative disease; major depressive disorder or anxiety disorder; heavy smoking (>20 cigarettes/day); alcohol or substance dependence; excessive caffeine intake (>2.5 cups/day)
Key Trial Info
Start Date :
October 20 2025
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 19 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07345546
Start Date
October 20 2025
End Date
December 19 2025
Last Update
April 8 2026
Active Locations (1)
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1
Prof. Dr. Cemil Taşçıoğlu Şehir Hastanesi
Istanbul, Istanbul, Turkey (Türkiye)