Status:

COMPLETED

Association Between Autonomic Dysfunction and Choroidal Vascularity Index in Fibromyalgia

Lead Sponsor:

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Conditions:

Fibromyalgia

Autonomic Dysfunction

Eligibility:

All Genders

18-50 years

Brief Summary

Fibromyalgia is frequently accompanied by autonomic nervous system dysfunction, often characterized by sympathetic predominance. Alterations in ocular microcirculation have been reported in the presen...

Detailed Description

This is a cross-sectional, observational case-control study planned to investigate the relationship between autonomic nervous system dysfunction and choroidal vascularity index (CVI) in patients diagn...

Eligibility Criteria

Inclusion Criteria:

  • Age 18-50 years, female or male
  • Fibromyalgia group: diagnosis of fibromyalgia according to 2016 ACR criteria
  • Ability and willingness to provide written informed consent
  • Adequate ocular media clarity suitable for OCT imaging
  • Control group: age- and sex-matched healthy volunteers

Exclusion Criteria:

  • Ocular exclusions: cataract or other media opacity; glaucoma or optic nerve disease; ocular surface disorders (e.g., dry eye disease); retinal diseases (e.g., diabetic retinopathy, macular disease); ocular surgery or eye/head trauma within the last 3 months; best-corrected visual acuity < 20/20; refractive error > ±3.00 diopters; intraocular pressure > 21 mmHg; use of topical ophthalmic medications
  • Systemic/neurologic exclusions: diabetes mellitus; hypertension; hyperlipidemia; thyroid disorders; inflammatory rheumatic/autoimmune diseases; polyneuropathy or neurodegenerative disease; major depressive disorder or anxiety disorder; heavy smoking (>20 cigarettes/day); alcohol or substance dependence; excessive caffeine intake (>2.5 cups/day)

Key Trial Info

Start Date :

October 20 2025

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

December 19 2025

Estimated Enrollment :

80 Patients enrolled

Trial Details

Trial ID

NCT07345546

Start Date

October 20 2025

End Date

December 19 2025

Last Update

April 8 2026

Active Locations (1)

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1

Prof. Dr. Cemil Taşçıoğlu Şehir Hastanesi

Istanbul, Istanbul, Turkey (Türkiye)