Status:
RECRUITING
Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation
Lead Sponsor:
Hospital San Carlos, Madrid
Collaborating Sponsors:
Instituto de Salud Carlos III
Conditions:
Atrial Fibrillation (AF)
Ablation Treatment
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The mechanisms that maintain persistent atrial fibrillation (AF) in humans remain unknown. In the research project PI18/01268 funded in the previous call for Strategic Action in Health, the group has ...
Detailed Description
The present research project proposes to characterize the physiology of persistent human AF after therapeutic interaction (ablation) with the "DFASI domains", exploring its impact on the dynamics and ...
Eligibility Criteria
Inclusion Criteria:
- Patients over 18 years of age with persistent AF lasting more than 6 months at the time of the experimental protocol (uninterrupted persistent AF) and clinical indication for an AF ablation procedure.
or
-Patients over 18 years of age with recurrent VF/VT and poor control with conventional pharmacological measures.
Exclusion Criteria:
- Lack of patient consent to participate in the study.
- In patients with persistent AF, contraindication for the use of adenosine.
- AF/VF/VPT secondary to endocrine-metabolic disorders and/or severe systemic disease (thyrotoxicosis, sepsis, pulmonary thromboembolism, etc.).
- Contraindications for cardiac catheterization (e.g., intracardiac thrombus).
- Impossibility of remote monitoring using an implantable Holter monitor or implantable defibrillator.
Key Trial Info
Start Date :
January 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT07390175
Start Date
January 20 2025
End Date
December 31 2026
Last Update
February 20 2026
Active Locations (1)
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1
Hospital Clínico San Carlos
Madrid, Madrid, Spain, 28040