Inclusion Criteria:

1. Male and female subjects aged 18-70 years, inclusive.
2. Availability for the 6-month duration of the clinical research study.
3. Good general health based on the opinion of the study investigator.
4. Signed Informed Consent Form.
5. Minimum of 20 natural teeth (excluding third molars).
6. Initial gingivitis index of at least 1.5 as determined by the use of the Loe and Silness Gingival Index.
7. Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).

Exclusion Criteria:

1. Be under orthodontic treatment.
2. Presence of partial removable dentures.
3. Tumor(s) of the soft or hard tissues of the oral cavity.
4. Participants with current moderate or severe periodontitis (periodontitis screening index [PSI] >2 in more than 2 sextants or PSI >3), and/or purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone.
5. Five or more carious lesions requiring immediate restorative treatment.
6. Antibiotic use any time during the one-month period prior to entry into the study.
7. Participation in any other clinical study or test panel within the one month prior to entry into the study.
8. Dental prophylaxis during the past two weeks prior to baseline examinations.
9. History of allergies to oral care/personal care consumer products or their ingredients.
10. On any prescription medicines that might interfere with the study outcome based on the examiner/PI opinion.
11. An existing medical condition that prohibits eating and/or drinking for periods up to 4 hours.
12. History of alcohol and/or drug abuse.
13. Self-reported pregnancy and/or lactating subjects.
14. Subjects with other oral diseases (including gingival hyperplasia, diseases of the oral mucosa), or any condition that the dental examiner considers exclusionary from the study.
15. Smokers or/and users of tobacco products.
16. Enrolled in an undergraduate, postgraduate, or academic dentistry program