Status:
RECRUITING
Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome
Lead Sponsor:
Cairo University
Conditions:
Amantadine
Duloxetine
Eligibility:
FEMALE
18-65 years
Phase:
NA
Brief Summary
This study aims to evaluate the additive effect of Amantadine or Duloxetine to Pregabalin on development of post mastectomy pain syndrome
Detailed Description
Post mastectomy pain syndrome (PMPS) is considered one of the most common types of CPSP with incidence ranging between 20% - 50%. Pregabalin is one of the drugs that can reduce the excitability of th...
Eligibility Criteria
Inclusion Criteria:
- Age from 18 to 65 years.
- American society of anesthesiologists (ASA) Physical status II, III.
- Body mass index (BMI): (20-40) kg/m2.
- Type of surgery: patients undergoing modified radical mastectomy for breast cancer.
Exclusion Criteria:
- Patient refusal.
- Patients with Known sensitivity or contraindication to drug used in the study.
- History of psychological disorders and/or chronic pain and drug abuse patients.
- Previous administration of antidepressants, anticonvulsants, or opioids before surgery.
- Severe respiratory or cardiac disorders.
- Advanced liver or kidney disease.
- Previous breast surgery
Key Trial Info
Start Date :
February 21 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT07421427
Start Date
February 21 2026
End Date
January 1 2027
Last Update
February 24 2026
Active Locations (1)
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1
Cairo University
Cairo, Egypt, 12613