Status:

RECRUITING

A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants

Lead Sponsor:

AbbVie

Conditions:

Healthy Volunteer

Eligibility:

All Genders

18-65 years

Phase:

PHASE1

Brief Summary

This is a Phase 1 study to investigate safety and pharmacokinetics of ABBV-722 and Upadacitinib following multiple oral doses in healthy adult participants.

Eligibility Criteria

Inclusion Criteria:

  • Laboratory values meet the criteria specified in the protocol.
  • A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile, and a 12-lead electrocardiogram (ECG).

Exclusion Criteria:

  • History of any clinically significant illness/infection/major febrile illness, hospitalization, or any surgical procedure within 30 days prior to the first dose of study drug.
  • Chronic recurring infection and/or active viral infection.
  • Consumption of alcohol, grapefruit products, Seville oranges, starfruit products or quinine/tonic water within the 72-hour period prior to study drug administration.
  • Use of tobacco or nicotine-containing products within 90 days prior to the first dose of study drug.
  • Evidence of dysplasia or history of malignancy (including lymphoma and leukemia) other than successfully treated non-metastatic cutaneous squamous cell, basal cell carcinoma or localized carcinoma in situ of the cervix.
  • History or evidence of active tuberculosis (TB) disease or latent TB infection
  • Prior exposure to ABBV-722 within 90 days prior to the first dose of study drug.

Key Trial Info

Start Date :

February 26 2026

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

August 1 2026

Estimated Enrollment :

32 Patients enrolled

Trial Details

Trial ID

NCT07425899

Start Date

February 26 2026

End Date

August 1 2026

Last Update

April 17 2026

Active Locations (1)

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1

Acpru /Id# 279285

Grayslake, Illinois, United States, 60030