Using Quick MRI Without Contrast Versus Ultrasound Every 6 Months to Detect Liver Cancer Early in Adults at High Risk Due to Liver Cirrhosis

What this Trial Is About

This research aims to improve the diagnosis of liver cancer in people at high risk due to liver cirrhosis. The study focuses on those with cirrhosis caused by conditions such as alcohol-related liver disease, fatty liver disease, hepatitis B and C, and genetic haemochromatosis. People with cirrhosis are usually monitored with ultrasound scans every 6 months, but ultrasound can miss some cancers. This trial evaluates whether a quick, non-contrast MRI scan performed every 6 months can better detect liver cancer compared to standard ultrasound surveillance. Participants will receive ultrasound scans every 6 months as part of their usual care and also undergo a non-contrast MRI scan at the same 6-month intervals for 30 months, totaling six visits. If either scan suggests possible liver cancer, a detailed MRI with contrast will be performed to confirm the diagnosis. At the end of 30 months, all participants will have a contrast MRI to ensure no cancers were missed. The study compares cancer detection rates between ultrasound and non-contrast MRI scans. During the study, participants will complete questionnaires about their quality of life, anxiety, and experience with both types of scans. Medical records will also be reviewed for relevant data. Researchers will measure diagnostic performance for liver cancer, cancer stage and size at diagnosis, the proportion receiving treatment aimed at cure, participant experiences, and long-term outcomes up to 10 years after the last MRI. The study spans from enrollment through 30 months of active monitoring with extended follow-up for long-term results.

Abbreviated Magnetic Resonance Imaging vs Ultrasound Surveillance for Liver Cancer dETection in People at High Risk of Developing Liver Cancer