Actively Recruiting
Abdominal Wall Transplantation for Reconstruction of Defects Alone or with Other Organ Transplants
Led by Duke University · Updated on 2026-01-07
5
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
L
Linda Cendales, MD
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the safety and effectiveness of abdominal wall transplantation to repair abdominal wall defects. This treatment may be done alone or along with another organ transplant. The study involves a small group of participants and aims to assess how well the transplanted abdominal wall restores function. Participants will receive either an isolated abdominal wall transplant or an abdominal wall transplant combined with another solid organ transplant. All participants will be given standard immunosuppression therapy similar to that used in other non-vascularized composite allograft organ transplants. The study will take place over 18 months at Duke University Medical Center. During the 18-month study period, participants will be closely monitored to see if the transplanted abdominal wall remains viable and functional. Researchers will evaluate the success of the transplant and monitor the participants’ health and response to treatment throughout this time. The primary measure is the number of subjects with a viable abdominal wall transplant at 18 months.
CONDITIONS
Brief Title
Abdominal Wall Transplant
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Candidates between 18 and 65 years old
- Willingness and legal ability to give consent
- Eligibility for non-vascularized composite allograft organ transplant at Duke if receiving abdominal wall with another organ transplant
You will not qualify if you...
- Malignancy at evaluation or history of malignancy that prevents transplantation
- Pregnancy: women must have a negative pregnancy test within 48 hours before transplant and agree to use two reliable contraception methods for at least 2 years post-transplant
- Medical reasons preventing general anesthesia
- Ongoing substance abuse or history of untreated substance abuse
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 18 months
Participants undergo abdominal wall transplantation either alone or in combination with another organ transplant, followed by immediate post-operative care.
Trial Site Locations
Total: 1 location
1
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
L
Linda Cendales, MD
K
Kadiyala Ravindra, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here