Actively Recruiting
Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation
Led by Hospital San Carlos, Madrid · Updated on 2026-02-20
78
Participants Needed
1
Research Sites
101 weeks
Total Duration
On this page
Sponsors
H
Hospital San Carlos, Madrid
Lead Sponsor
I
Instituto de Salud Carlos III
Collaborating Sponsor
AI-Summary
What this Trial Is About
The mechanisms that maintain persistent atrial fibrillation (AF) in humans remain unknown. In the research project PI18/01268 funded in the previous call for Strategic Action in Health, the group has demonstrated that the hierarchical organization of (i) rotational domains, (ii) frequency domains and (iii) physiological responses to pharmacological provocation with adenosine, allow the identification of domains of high-frequency reentrant activity (hereinafter "DFASI domains") maintainers of AF. As a result, the investigators have developed non-invasive technological models and quantitative indices for the efficient localization of these domains, whose therapeutic approach through ablation has allowed to improve the clinical results of the patients studied, safely without increase in complications (Calvo D et al. Sci Rep. 2025 Dec 16;15(1):43892). Likewise, and in response to the objectives of the PI18/01268 project, the investigators have identified hierarchical organization patterns in human ventricular fibrillation (VF) that indicate the existence of universal fibrillatory mechanisms, opening the door to new therapeutic opportunities (Europace 2022;24\[11\]:1788-1799).
CONDITIONS
Official Title
Ablation of Human Cardiac Fibrillation Based on Models of Hierarchical Organization of Tissue Excitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years of age with persistent atrial fibrillation lasting more than 6 months and a clinical indication for AF ablation
- Patients over 18 years of age with recurrent ventricular fibrillation or ventricular tachycardia not well controlled with conventional medications
You will not qualify if you...
- Lack of patient consent to participate in the study
- Contraindication for adenosine use in patients with persistent AF
- AF, VF, or VT caused by endocrine-metabolic disorders or severe systemic diseases such as thyrotoxicosis, sepsis, or pulmonary thromboembolism
- Contraindications for cardiac catheterization, including intracardiac thrombus
- Inability to undergo remote monitoring with an implantable Holter monitor or implantable defibrillator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hospital Clínico San Carlos
Madrid, Madrid, Spain, 28040
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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