Actively Recruiting
Ablative Carbon Ion Radiotherapy With Pencil Beam Scanning for Locally Advanced Unresectable Pancreatic Cancer
Led by Shanghai Proton and Heavy Ion Center · Updated on 2023-12-07
48
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to investigate the clinical efficacy and safety of ablative carbon ion radiotherapy for locally advanced unresectable pancreatic cancer with pencil beam scanning and simultaneous integrated boost (SIB) technology.
CONDITIONS
Official Title
Ablative Carbon Ion Radiotherapy With Pencil Beam Scanning for Locally Advanced Unresectable Pancreatic Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to sign written informed consent
- Ductal adenocarcinoma of the pancreas confirmed by histopathology or cytopathology
- No distant metastasis by imaging; locally advanced unresectable pancreatic cancer defined as T4N0-2M0, Stage III
- Maximum diameter of pancreatic tumor and positive lymph node is 7 cm or less
- Pancreatic lesion or positive lymph node does not invade stomach, duodenum, or small intestine
- Eastern Cooperative Oncology Group (ECOG) performance score 0 or 1
- Adequate bone marrow function: neutrophils 61.5�d7109/L, platelets 100�d7109/L, hemoglobin 10.0 g/dL
- Adequate liver function: total bilirubin <1.5 times upper normal limit, aminotransferase <2.5 times upper normal limit
- Adequate kidney function: serum creatinine <2 mg/dL or creatinine clearance >50 mL/min
You will not qualify if you...
- More than one primary pancreatic lesion
- Tumor invasion of adjacent digestive tract
- Previous radiation therapy
- Previous local treatments for pancreatic cancer such as HIFU or irreversible electroporation
- Inability to meet irradiation dose constraints for organs at risk
- History of other malignant tumors
- Unable or unwilling to understand treatment purpose or sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Proton and Heavy Ion Center
Shanghai, China, 201315
Actively Recruiting
Research Team
Z
Zheng Wang, MD, PhD
CONTACT
G
Guo-Liang Jiang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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